Effect of remdesivir post-exposure prophylaxis and treatment on pathogenesis of measles in rhesus macaques.

ABSTRACT: Measles is a systemic disease initiated in the respiratory tract with widespread measles virus (MeV) infection of lymphoid tissue. Mortality can be substantial, but no licensed antiviral therapy is available. We evaluated both post-exposure prophylaxis and treatment with remdesivir, a broad-spectrum antiviral, using a well-characterized rhesus macaque model of measles. Animals were treated with intravenous remdesivir for 12 days beginning either 3 days after intratracheal infection (post-exposure prophylaxis, PEP) or 11 days after infection at the onset of disease (late treatment, LT). As PEP, remdesivir lowered levels of viral RNA in peripheral blood mononuclear cells, but RNA rebounded at the end of the treatment period and infectious virus was continuously recoverable. MeV RNA was clear

SUBMITTER: Peart Akindele NA 

PROVIDER: S-EPMC10116456 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature