Contributions of transient and sustained reward to memory formation.

ABSTRACT: Reward benefits to memory formation have been robustly linked to dopaminergic activity. Despite the established characterization of dopaminergic mechanisms as operating at multiple timescales, potentially supporting distinct functional outcomes, the temporal dynamics by which reward might modulate memory encoding are just beginning to be investigated. In the present study, we leveraged a mixed block/event experimental design to disentangle transient and sustained reward influences on task engagement and subsequent recognition memory in an adapted monetary-incentive-encoding (MIE) paradigm. Across three behavioral experiments, transient and sustained reward modulation of item and context memory was probed, at both 24-h and ~ 15-min retention intervals, to investigate the importance of overn

SUBMITTER: Gholston AS 

PROVIDER: S-EPMC10116487 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature