Prognostic stratification of oropharyngeal cancer patients in a betel nut chewing and low HPV area.

ABSTRACT:

Background

This study aimed to establish a simple predictive model for oropharyngeal cancer (OPC) in an area with a relatively low prevalence of human papillomavirus (HPV) and frequent betel nut chewing.

Methods

A total of 116 patients with OPC were recruited from the clinical research database of a referral cancer center between 2013 and 2018. Patient characteristics-including age, gender, tumor stage, differentiation, and treatment modality-were extracted from the database. Patients diagnosed after 2018 were staged using the 7th AJCC staging system to explore the impact of extra-nodal tumor extension (ENE) on survival. Immunohistochemical analysis was performed for p16, epidermal growth factor receptor (EGFR), p53, and programmed cell death ligand 1 (PD-L1). ENE status was

SUBMITTER: Lee HP 

PROVIDER: S-EPMC10116661 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature