Not recommended fixed-dose antibiotic combinations in low- and middle-income countries - the example of Tanzania.

ABSTRACT:

Background

Fixed-dose combinations (FDC) are medicine formulations that combine two or more ingredients in fixed ratios in a single dose form. Although advantageous in tuberculosis and malaria (efficacy, adherence, protection against resistance), only a few antibiotic FDC (FDC-AB) have been developed along full microbiological, pharmacological and clinical validation and safety studies. The World Health Organization (WHO) database of Access, Watch and Reserve (AWaRe) antibiotics contains, since 2021, a list of "Not Recommended" FDC-AB (n = 103) which are rejected for use in clinical practice. BODY: The share of non-recommended FDC-AB in global antimicrobial use (2000-2015) was < 3% but substantially higher in middle income countries. The share increases over time, but recent data p

SUBMITTER: Vliegenthart-Jongbloed K 

PROVIDER: S-EPMC10116708 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature