Causal effects of modifiable risk factors on kidney stones: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Increasing epidemiological studies demonstrated that modifiable risk factors affected the risk of kidney stones. We aimed to systemically assess these causal associations using a bidirectional Mendelian randomization study.

Methods

We obtained instrumental variables related to each exposure at the genome-wide significant threshold (P < 5 × 10^-8). Summary level data for outcomes from the FinnGen consortium and UK Biobank were utilized in the discovery and replication stage. The Inverse-variance weighted (IVW) method was used as the primary analysis, with additional sensitivity analyses and fix-effect meta-analysis to verify the robustness of IVW results.

Results

Among 46 risk factors, five were significantly associated with nephrolithiasis risk in

SUBMITTER: Liu W 

PROVIDER: S-EPMC10116718 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature