Serum- and xeno-free culture of human umbilical cord perivascular cells for pediatric heart valve tissue engineering.

ABSTRACT: Constructs currently used to repair or replace congenitally diseased pediatric heart valves lack a viable cell population capable of functional adaptation in situ, necessitating repeated surgical intervention. Heart valve tissue engineering (HVTE) can address these limitations by producing functional living tissue in vitro that holds the potential for somatic growth and remodelling upon implantation. However, clinical translation of HVTE strategies requires an appropriate source of autologous cells that can be non-invasively harvested from mesenchymal stem cell (MSC)-rich tissues and cultured under serum- and xeno-free conditions. To this end, we evaluated human umbilical cord perivascular cells (hUCPVCs) as a promising cell source for in vitro production of engineered heart valve tissue.

SUBMITTER: Parvin Nejad S 

PROVIDER: S-EPMC10116794 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature