Optimizing yeast for high-level production of kaempferol and quercetin.

ABSTRACT:

Background

Two important flavonoids, kaempferol and quercetin possess remarkably potent biological impacts on human health. However, their structural complexity and low abundance in nature make both bulk chemical synthesis and extraction from native plants difficult. Therefore microbial production via heterologous expression of plant enzymes can be a safe and sustainable route for their production. Despite several attempts reported in microbial hosts, the production levels of kaempferol and quercetin still stay far behind compared to many other microbial-produced flavonoids.

Results

In this study, Saccharomyces cerevisiae was engineered for high production of kaempferol and quercetin in minimal media from glucose. First, the kaempferol biosynthetic pathway was reconstructed

SUBMITTER: Tartik M 

PROVIDER: S-EPMC10116799 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature