Prenatal PM_2.5 exposure impairs spatial learning and memory in male mice offspring: from transcriptional regulation to neuronal morphogenesis.

ABSTRACT:

Background

As one of the environmental risk factors for human health, atmospheric fine particulate matter (PM_2.5) contributes to cognitive deterioration in addition to respiratory and cardiovascular injuries. Recently, increasing evidence implicates that PM_2.5 inhalation can affect neurological functions in offspring, but the sex-specific outcomes and the underlying biological processes are largely unknown.

Objectives

To observe the influence of prenatal PM_2.5 exposure on cognitive performance in offspring, to elucidate the neuronal morphological alterations and possible transcriptional regulation based on mRNA-sequencing (mRNA-Seq) data after birth, and to determine the key components of PM_2.5 contributing to the adverse effects.<

SUBMITTER: Hou Y 

PROVIDER: S-EPMC10116824 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature