Decidual derived exosomal miR-99a-5p targets Ppp2r5a to inhibit trophoblast invasion in response to CeO₂NPs exposure.

ABSTRACT:

Background

The biological effects of cerium dioxide nanoparticles (CeO₂NPs), a novel material in the biomedical field, have attracted widespread attention. Our previous study confirmed that exposure to CeO₂NPs during pregnancy led to abnormal trophoblast invasion during early placental development, thereby impairing placental development. The potential mechanisms may be related to low-quality decidualization triggered by CeO₂NPs exposure, such as an imbalance in trophoblast invasion regulators secreted by decidual cells. However, the intermediate link mediating the "dialogue" between decidual cells and trophoblasts during this process remains unclear. As an important connection between cells, exosomes participate in the "dialogue" between endometria

SUBMITTER: Zhong H 

PROVIDER: S-EPMC10116836 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature