Combination release of chemokines from coated coils to target aneurysm healing.

ABSTRACT:

Background

Monocyte chemoattractant protein 1 (MCP-1) and osteopontin (OPN) have been identified separately as key mediators of the aneurysm healing process following coil embolization in the rodent model. The ability of protein coated coils to accelerate this process is currently unknown.

Objective

To create coils coated with both MCP-1 and OPN to target aneurysm healing.

Methods

We used a polymer (poly(glycolide-co-caprolactone)) (Rao pharmaceuticals) (CG910) to test whether coils could be dual coated with active proteins with sequential reliable release. Coils were coated with poly-DL-lactic glycolic acid (PLGA), CG910, and subsequently dipped with protein OPN (inner layer for delayed release) and MCP-1 (outer layer for initial release). Release assays were used to

SUBMITTER: Laurent D 

PROVIDER: S-EPMC10116990 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature