Safety and feasibility of transcranial direct current stimulation stratified by corticospinal organization in children with hemiparesis.

ABSTRACT: Children with hemiparesis (CWH) due to stroke early in life face lifelong impairments in motor function. Transcranial direct current stimulation (tDCS) may be a safe and feasible adjuvant therapy to augment rehabilitation. Given the variability in outcomes following tDCS, tailored protocols of tDCS are required. We evaluated the safety, feasibility, and preliminary effects of a single session of targeted anodal tDCS based on individual corticospinal tract organization on corticospinal excitability. Fourteen CWH (age = 13.8 ± 3.63) were stratified into two corticospinal organization subgroups based on transcranial magnetic stimulation (TMS)-confirmed motor evoked potentials (MEP): ipsilesional MEP presence (MEP_IL+) or absence (MEP_IL-). Subgroups were randomized to real

SUBMITTER: Nemanich ST 

PROVIDER: S-EPMC10117060 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature