Toxoplasma gondii AP2XII-2 Contributes to Transcriptional Repression for Sexual Commitment.

ABSTRACT: Toxoplasma gondii is a widespread protozoan parasite that has a significant impact on human and veterinary health. The parasite undergoes a complex life cycle involving multiple hosts and developmental stages. How Toxoplasma transitions between life cycle stages is poorly understood yet central to controlling transmission. Of particular neglect are the factors that contribute to its sexual development, which takes place exclusively in feline intestines. While epigenetic repressors have been shown to play an important role in silencing the spurious gene expression of sexually committed parasites, the specific factors that recruit this generalized machinery to the appropriate genes remain largely unexplored. Here, we establish that a member of the AP2 transcription factor family, AP2X

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC10117075 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature