Integrated single-cell RNA-seq analysis reveals the vital cell types and dynamic development signature of atherosclerosis.

ABSTRACT: Introduction: In the development of atherosclerosis, the remodeling of blood vessels is a key process involving plaque formation and rupture. So far, most reports mainly believe that macrophages, smooth muscle cells, and endothelial cells located at the intima and media of artery play the key role in this process. Few studies had focused on whether fibroblasts located at adventitia are involved in regulating disease process. Methods and results: In this study, we conducted in-depth analysis of single-cell RNA-seq data of the total of 18 samples from healthy and atherosclerotic arteries. This study combines several analysis methods including transcription regulator network, cell-cell communication network, pseudotime trajectory, gene set enrichment analysis, and differential e

SUBMITTER: Shao X 

PROVIDER: S-EPMC10117136 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature