Posttranslational modifications induce autoantibodies with risk prediction capability in patients with small cell lung cancer.

ABSTRACT: Small cell lung cancer (SCLC) elicits the generation of autoantibodies that result in unique paraneoplastic neurological syndromes. The mechanistic basis for the formation of such autoantibodies is largely unknown but is key to understanding their etiology. We developed a high-dimensional technique that enables detection of autoantibodies in complex with native antigens directly from patient plasma. Here, we used our platform to screen 1009 human plasma samples for 3600 autoantibody-antigen complexes, finding that plasma from patients with SCLC harbors, on average, fourfold higher disease-specific autoantibody signals compared with plasma from patients with other cancers. Across three independent SCLC cohorts, we identified a set of common but previously unknown autoantibodies that are pro

SUBMITTER: Lastwika KJ 

PROVIDER: S-EPMC10117289 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature