Treatment issues in recurrent Clostridioides difficile infections and the possible role of germinants.

ABSTRACT: Clostridioides difficile is the number one cause of hospital-acquired infections in the United States and one of the CDC's urgent-level pathogen threats. The inflammation caused by pathogenic C. difficile results in diarrhea and pseudomembranous colitis. Patients who undergo clinically successful treatment for this disease commonly experience recurrent infections. Current treatment options can eradicate the vegetative cell form of the bacteria but do not impact the spore form, which is impervious to antibiotics and resists conventional environmental cleaning procedures. Antibiotics used in treating C. difficile infections (CDI) often do not eradicate the pathogen and can prevent regeneration of the microbiome, leaving them vulnerable to recurrent CDI and future infecti

SUBMITTER: Budi N 

PROVIDER: S-EPMC10117431 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature