A global data-driven census of Salmonella small proteins and their potential functions in bacterial virulence.

ABSTRACT: Small proteins are an emerging class of gene products with diverse roles in bacterial physiology. However, a full understanding of their importance has been hampered by insufficient genome annotations and a lack of comprehensive characterization in microbes other than Escherichia coli. We have taken an integrative approach to accelerate the discovery of small proteins and their putative virulence-associated functions in Salmonella Typhimurium. We merged the annotated small proteome of Salmonella with new small proteins predicted with in silico and experimental approaches. We then exploited existing and newly generated global datasets that provide information on small open reading frame expression during infection of epithelial cells (dual RNA-seq), contribution

SUBMITTER: Venturini E 

PROVIDER: S-EPMC10117436 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature