A meta-analysis and experimental data for multidrug resistance genes in breast cancer.

ABSTRACT:

Background

Increasing trend of breast cancer incidence worldwide is a known fact. This curable disease may become fatal if drug resistance is developed leading to metastatic cancerous tissue.

Objective

This is a two parts study; a meta-analysis exploring association of drug resistance (mdr1 and ABCG2) genes with breast cancer and mutational association with molecular subtypes of cancer. Methods: PCR-SSCP for genomic polymorphisms and RT-PCR for expression analysis were performed.

Results

C3435T polymorphism of mdr1 gene was most commonly studied mutation with contradictory results. Association of ABCG2 gene mutations with untreated breast cancer was reported only by one study so far. Regarding current genomic analysis of mdr1 gene, three novel mutations were found in

SUBMITTER: Zaib S 

PROVIDER: S-EPMC10117449 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature