Investigation of the effects of mir-219-1 gene variants on the development of disease in non-small cell lung cancer patients.

ABSTRACT:

Background

Various variants of the miR-219-1 gene are one of the first genes associated with NSCLC prognosis in the literature.

Objectives

We aimed to genotype two different variants of the miR-219-1 gene and to investigate to using of the result as a biomarker in the diagnosis and treatment of NSCLC.

Materials and methods

The patients were chosen according to International NSCLC criteria and genomic DNA was isolated from blood (138 patients and 100 healthy individuals). Then qRT-PCR was applied to determine the rs213210 and rs421446 variants of miR-219-1 gene polymorphisms. Allele and genotype frequencies were compared using Pearson's chi-square and Fisher's exact tests test.

Results

We found that TT genotype (p=0,381) in rs213210 compared with CC genotype (p=

SUBMITTER: Tas SK 

PROVIDER: S-EPMC10117453 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature