Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential.

ABSTRACT: Global antimicrobial resistance is a health crisis that can change the face of modern medicine. Exploring diverse natural habitats for bacterially-derived novel antimicrobial compounds has historically been a successful strategy. The deep-sea presents an exciting opportunity for the cultivation of taxonomically novel organisms and exploring potentially chemically novel spaces. In this study, the draft genomes of 12 bacteria previously isolated from the deep-sea sponges Phenomena carpenteri and Hertwigia sp. are investigated for the diversity of specialized secondary metabolites. In addition, early data support the production of antibacterial inhibitory substances produced from a number of these strains, including activity against clinically relevant pathogens Acinetobacter

SUBMITTER: Hesketh-Best PJ 

PROVIDER: S-EPMC10117722 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature