Evaluating the association between dietary salt intake and the risk of atrial fibrillation using Mendelian randomization.

ABSTRACT:

Background

Previous studies have suggested that dietary salt intake affects atrial fibrillation (AF); however, the causal association between them still remains unclear. Thus, we conducted this Mendelian randomization (MR) study to explore the correlation between them.

Methods

Genetic instruments for dietary salt intake were from a genome-wide association study (GWAS), which included 462,630 European individuals. Summary-level data for AF were obtained from another published GWAS (22,068 cases and 116,926 controls). The inverse-variance weighting (IVW) method was performed as the primary MR analysis. Multiple MR methods, including Robust Adjusted Profile Score (MR-RAPS), maximum likelihood estimation, and Mendelian randomization pleiotropy residual sum and outlier test (MR-P

SUBMITTER: Wang S 

PROVIDER: S-EPMC10117818 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature