Prognostic prediction based on histopathologic features of tumor microenvironment in colorectal cancer.

ABSTRACT:

Purpose

To automatically quantify colorectal tumor microenvironment (TME) in hematoxylin and eosin stained whole slide images (WSIs), and to develop a TME signature for prognostic prediction in colorectal cancer (CRC).

Methods

A deep learning model based on VGG19 architecture and transfer learning strategy was trained to recognize nine different tissue types in whole slide images of patients with CRC. Seven of the nine tissue types were defined as TME components besides background and debris. Then 13 TME features were calculated based on the areas of TME components. A total of 562 patients with gene expression data, survival information and WSIs were collected from The Cancer Genome Atlas project for further analysis. A TME signature for prognostic prediction was developed a

SUBMITTER: Shi L 

PROVIDER: S-EPMC10117979 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature