MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8⁺ T Cell Responses.

ABSTRACT: MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the immune system and immune responses. Using miRNA microarray profiling, we characterized the expression profile of naive and in vivo generated murine effector antiviral CD8⁺ T cells. We observed that out of 362 measurable mature miRNAs, 120 were differentially expressed by at least 2-fold in influenza-specific effector CD8⁺ CTLs compared with naive CD8⁺ T cells. One miRNA found to be highly downregulated on both strands in effector CTLs was miR-139. Because previous studies have indicated a role for miR-139-mediated regulation of CTL effector responses, we hypothesized that deletion of miR-139 would enhance

SUBMITTER: Hope JL 

PROVIDER: S-EPMC10118001 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature