Metagenomic insights into the composition and function of the gut microbiota of mice infected with Toxoplasma gondii.

ABSTRACT:

Introduction

Despite Toxoplasma gondii infection leading to dysbiosis and enteritis, the function of gut microbiota in toxoplasmosis has not been explored.

Methods

Here, shotgun metagenomics was employed to characterize the composition and function of mouse microbial community during acute and chronic T. gondii infection, respectively.

Results

The results revealed that the diversity of gut bacteria was decreased immediately after T. gondii infection, and was increased with the duration of infection. In addition, T. gondii infection led to gut microbiota dysbiosis both in acute and chronic infection periods. Therein, several signatures, including depression of Firmicutes to Bacteroidetes ratio and infection-enriched Proteobacteria, were observed in the chronic period,

SUBMITTER: Meng JX 

PROVIDER: S-EPMC10118048 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature