A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases.

ABSTRACT: Genes associated with risk for brain disease exhibit characteristic expression patterns that reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of disease risk genes provide a molecular-based signature, based on differential co-expression, that is often unique to that disease. Brain diseases can be compared and aggregated based on the similarity of their signatures which often associates diseases from diverse phenotypic classes. Analysis of 40 common human brain diseases identifies 5 major transcriptional patterns, representing tumor-related, neurodegenerative, psychiatric and substance abuse, and 2 mixed groups of diseases affecting basal ganglia and hypothalamus. Further, for diseases with enriched expression in cortex, single-nucleus data in the midd

SUBMITTER: Zeighami Y 

PROVIDER: S-EPMC10118126 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature