Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons.

ABSTRACT: The formation of neural circuits requires extensive interactions of cell-surface proteins to guide axons to their correct target neurons. Trans-cellular interactions of the adhesion G protein-coupled receptor latrophilin-2 (Lphn2) with its partner teneurin-3 instruct the precise assembly of hippocampal networks by reciprocal repulsion. Lphn2 acts as a repulsive receptor in distal CA1 neurons to direct their axons to the proximal subiculum, and as a repulsive ligand in the proximal subiculum to direct proximal CA1 axons to the distal subiculum. It remains unclear if Lphn2-mediated intracellular signaling is required for its role in either context. Here, we show that Lphn2 couples to Gα_12/13 in heterologous cells; this coupling is increased by constitutive exposure of the t

SUBMITTER: Pederick DT 

PROVIDER: S-EPMC10118387 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature