Riparin-B as a Potential Inhibitor of AdeABC Efflux System from Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is an important opportunistic pathogen that causes serious health-related infections, especially in intensive care units. The present study aimed to investigate the antimicrobial activity of Riparin-B (Rip-B) alone and in association with norfloxacin against multidrug-resistant clinical isolates of A. baumannii. For this, the minimum inhibitory concentrations were determined by the microdilution method. For the evaluation of resistance-modulating activity, MIC values for antibiotics were determined in the presence or absence of subinhibitory concentrations of Rip-B or chlorpromazine (CPZ). The AdeABC-AdeRS efflux system genes from these isolates were detected by PCR. Docking studies were also carried out to evaluate the interaction of Riparin-B and the

SUBMITTER: Leao PVS 

PROVIDER: S-EPMC10118900 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature