Diagnostic utility of DREAM gene mRNA levels in thyroid tumours.

ABSTRACT:

Objective

The transcriptional repressor DREAM is involved in thyroid-specific gene expression, thyroid enlargement and nodular development, but its clinical utility is still uncertain. In this study we aimed to investigate whether DREAM mRNA levels differ in different thyroid tumors and how this possible difference would allow the use of DREAM gene expression as molecular marker for diagnostic and/or prognosis purpose.

Materials and methods

We quantified DREAM gene mRNA levels and investigated its mutational status, relating its expression and genetic changes to diagnostic and prognostic features of 200 thyroid tumors, being 101 malignant [99 papillary thyroid carcinomas (PTC) and 2 anaplastic thyroid carcinomas] and 99 benign thyroid lesions [49 goiter and 50 follicular ade

SUBMITTER: Batista FA 

PROVIDER: S-EPMC10118984 | biostudies-literature | 2018 Mar-Apr

REPOSITORIES: biostudies-literature