Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease.

ABSTRACT: Failed proteostasis is a well-documented feature of Alzheimer's disease, particularly, reduced protein degradation and clearance. However, the contribution of failed proteostasis to neuronal circuit dysfunction is an emerging concept in neurodegenerative research and will prove critical in understanding cognitive decline. Our objective is to convey Alzheimer's disease progression with the growing evidence for a bidirectional relationship of sleep disruption and proteostasis failure. Proteostasis dysfunction and tauopathy in Alzheimer's disease disrupts neurons that regulate the sleep-wake cycle, which presents behavior as impaired slow wave and rapid eye movement sleep patterns. Subsequent sleep loss further impairs protein clearance. Sleep loss is a defined feature seen early in many neur

SUBMITTER: Morrone CD 

PROVIDER: S-EPMC10119020 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature