Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis.

ABSTRACT:

Aims

To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age.

Methods and results

Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was <10 years

SUBMITTER: Elhakeem A 

PROVIDER: S-EPMC10119029 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature