Lipoprotein(a) levels in children with suspected familial hypercholesterolaemia: a cross-sectional study.

ABSTRACT:

Aims

Familial hypercholesterolaemia (FH) predisposes children to the early initiation of atherosclerosis and is preferably diagnosed by DNA analysis. Yet, in many children with a clinical presentation of FH, no mutation is found. Adult data show that high levels of lipoprotein(a) [Lp(a)] may underlie a clinical presentation of FH, as the cholesterol content of Lp(a) is included in conventional LDL cholesterol measurements. As this is limited to adult data, Lp(a) levels in children with and without (clinical) FH were evaluated.

Methods and results

Children were eligible if they visited the paediatric lipid clinic (1989-2020) and if Lp(a) measurement and DNA analysis were performed. In total, 2721 children (mean age: 10.3 years) were included and divided into four groups: 1931

SUBMITTER: de Boer LM 

PROVIDER: S-EPMC10119030 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature