Regulation of early diagnosis and prognostic markers of lung adenocarcinoma in immunity and hypoxia.

ABSTRACT: Lung adenocarcinoma is still cancer with the highest mortality. Hypoxia and immunity play an essential role in the occurrence and development of tumors. Therefore, this study is mainly to find new early diagnosis and prognosis markers and explore the relationship among the markers and immunity and hypoxia, to improve the prognosis of patients. Firstly, based on the clinical database in TCGA, we determined the most critical clinicopathological parameters affecting the prognosis of patients through a variety of analysis methods. According to pathological parameters, logistic most minor absolute contraction selection operator (lasso), univariate and multivariate regression analysis, the risk genes related to early prognosis were screened, and the risk model was established. Then, in different

SUBMITTER: Sun K 

PROVIDER: S-EPMC10119119 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature