Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate.

ABSTRACT: Longitudinal bone growth relies on endochondral ossification in the cartilaginous growth plate, where chondrocytes accumulate and synthesize the matrix scaffold that is replaced by bone. The chondroprogenitors in the resting zone maintain the continuous turnover of chondrocytes in the growth plate. Malnutrition is a leading cause of growth retardation in children; however, after recovery from nutrient deprivation, bone growth is accelerated beyond the normal rate, a phenomenon termed catch-up growth. Although nutritional status is a known regulator of long bone growth, it is largely unknown whether and how chondroprogenitor cells respond to deviations in nutrient availability. Here, using fate-mapping analysis in Axin2Cre^ERT2 mice, we showed that dietary restriction increased th

SUBMITTER: Oichi T 

PROVIDER: S-EPMC10119120 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature