Multilayer networks of plasmid genetic similarity reveal potential pathways of gene transmission.

ABSTRACT: Antimicrobial resistance (AMR) is a significant threat to public health. Plasmids are principal vectors of AMR genes, significantly contributing to their spread and mobility across hosts. Nevertheless, little is known about the dynamics of plasmid genetic exchange across animal hosts. Here, we use theory and methodology from network and disease ecology to investigate the potential of gene transmission between plasmids using a data set of 21 plasmidomes from a single dairy cow population. We constructed a multilayer network based on pairwise plasmid genetic similarity. Genetic similarity is a signature of past genetic exchange that can aid in identifying potential routes and mechanisms of gene transmission within and between cows. Links between cows dominated the transmission network, and p

SUBMITTER: Shapiro JT 

PROVIDER: S-EPMC10119158 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature