Ontology highlight
ABSTRACT:
SUBMITTER: Gola L
PROVIDER: S-EPMC10119225 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Gola Lukas L Bierhansl Laura L Csatári Júlia J Schroeter Christina B CB Korn Lisanne L Narayanan Venu V Cerina Manuela M Abdolahi Sara S Speicher Anna A Hermann Alexander M AM König Simone S Dinkova-Kostova Albena T AT Shekh-Ahmad Tawfeeq T Meuth Sven G SG Wiendl Heinz H Gorji Ali A Pawlowski Matthias M Kovac Stjepana S
Cellular and molecular life sciences : CMLS 20230421 5
Hyperexcitability is associated with neuronal dysfunction, cellular death, and consequently neurodegeneration. Redox disbalance can contribute to hyperexcitation and increased reactive oxygen species (ROS) levels are observed in various neurological diseases. NOX4 is an NADPH oxidase known to produce ROS and might have a regulating function during oxidative stress. We, therefore, aimed to determine the role of NOX4 on neuronal firing, hyperexcitability, and hyperexcitability-induced changes in n ...[more]