Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies.

ABSTRACT: Pharmacokinetic modelling with arterial sampling is the gold standard for analysing dynamic PET data of the brain. However, the invasive character of arterial sampling prevents its widespread clinical application. Several methods have been developed to avoid arterial sampling, in particular reference region methods. Unfortunately, for some tracers or diseases, no suitable reference region can be defined. For these cases, other potentially non-invasive approaches have been proposed: (1) a population based input function (PBIF), (2) an image derived input function (IDIF), or (3) simultaneous estimation of the input function (SIME). This systematic review aims to assess the correspondence of these non-invasive methods with the gold standard. Studies comparing non-invasive pharmacokinetic mode

SUBMITTER: van der Weijden CWJ 

PROVIDER: S-EPMC10119247 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature