Secretin modulates appetite via brown adipose tissue-brain axis.

ABSTRACT:

Purpose

Secretin activates brown adipose tissue (BAT) and induces satiation in both mice and humans. However, the exact brain mechanism of this satiety inducing, secretin-mediated gut-BAT-brain axis is largely unknown.

Methods and results

In this placebo-controlled, single-blinded neuroimaging study, firstly using [¹⁸F]-fluorodeoxyglucose (FDG) PET measures (n = 15), we established that secretin modulated brain glucose consumption through the BAT-brain axis. Predominantly, we found that BAT and caudate glucose uptake levels were negatively correlated (r = -0.54, p = 0.037) during secretin but not placebo condition. Then, using functional magnetic resonance imaging (fMRI; n = 14), we found that secretin improved inhibitory control and downregulated the brain respon

SUBMITTER: Sun L 

PROVIDER: S-EPMC10119257 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature