The Ties That Bind: Glial Transplantation in White Matter Ischemia and Vascular Dementia.

ABSTRACT: White matter injury is a progressive vascular disease that leads to neurological deficits and vascular dementia. It comprises up to 30% of all diagnosed strokes, though up to ten times as many events go undiagnosed in early stages. There are several pathologies that can lead to white matter injury. While some studies suggest that white matter injury starts as small infarcts in deep penetrating blood vessels in the brain, others point to the breakdown of endothelial function or the blood-brain barrier as the primary cause of the disease. Whether due to local endothelial or BBB dysfunction, or to local small infarcts (or a combination), white matter injury progresses, accumulates, and expands from preexisting lesions into adjacent white matter to produce motor and cognitive deficits that pre

SUBMITTER: Carmichael ST 

PROVIDER: S-EPMC10119342 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature