Development and validation of an insulin resistance model for a population without diabetes mellitus and its clinical implication: a prospective cohort study.

ABSTRACT:

Background

Insulin resistance (IR) is associated with diabetes mellitus, cardiovascular disease (CV), and mortality. Few studies have used machine learning to predict IR in the non-diabetic population.

Methods

In this prospective cohort study, we trained a predictive model for IR in the non-diabetic populations using the US National Health and Nutrition Examination Survey (NHANES, from JAN 01, 1999 to DEC 31, 2012) database and the Taiwan MAJOR (from JAN 01, 2008 to DEC 31, 2017) database. We analysed participants in the NHANES and MAJOR and participants were excluded if they were aged <18 years old, had incomplete laboratory data, or had DM. To investigate the clinical implications (CV and all-cause mortality) of this trained model, we tested it with the Taiwan biobank (TWB

SUBMITTER: Tsai SF 

PROVIDER: S-EPMC10119497 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature