CAR-modified immune cells as a rapidly evolving approach in the context of cancer immunotherapies.

ABSTRACT: Nowadays, one of the main challenges clinicians face is malignancies. Through the progression of technology in recent years, tumor nature and tumor microenvironment (TME) can be better understood. Because of immune system involvement in tumorigenesis and immune cell dysfunction in the tumor microenvironment, clinicians encounter significant challenges in patient treatment and normal function recovery. The tumor microenvironment can stop the development of tumor antigen-specific helper and cytotoxic T cells in the tumor invasion process. Tumors stimulate the production of proinflammatory and immunosuppressive factors and cells that inhibit immune responses. Despite the more successful outcomes, the current cancer therapeutic approaches, including surgery, chemotherapy, and radiotherapy, hav

SUBMITTER: Faeq MH 

PROVIDER: S-EPMC10119530 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature