Identification of novel prognostic model based on homologous recombination deficiency associated lncRNAs in lung adenocarcinoma.

ABSTRACT:

Background

Non-small cell lung cancer with homologous recombination deficiency (HRD) was revealed to have better response to immunotherapy. Long non-coding RNAs (lncRNAs) modulate multiple processes including HRD acting as potential biomarkers in tumors. The function of HRD-associated lncRNAs in lung cancer arouses our interests.

Methods

Two independent cohorts were enrolled containing 838 lung adenocarcinoma (LUAD) patients. HRD-associated lncRNAs were defined as the lncRNAs that were differential expressed in high-HRD group and low-HRD group which were classified in accordance with the HRD score. The least absolute shrinkage and selection operator cox regression was employed to construct a signature according to prognostic HRD-associated lncRNAs. The signature robustness w

SUBMITTER: Liu X 

PROVIDER: S-EPMC10119576 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature