Skeletal muscle fat in individuals with rheumatoid arthritis compared to healthy adults.

ABSTRACT:

Objective

To compare skeletal muscle fat (SMF), intermuscular adipose tissue (IMAT) and subcutaneous adipose tissue (SAT) between individuals with rheumatoid arthritis (RA), and healthy individuals of the same age, and healthy individuals at least 10 years older than those with RA.

Methods

Two cross-sectional studies. In the first study, RA subjects were matched by age, sex, and BMI with healthy adults. In the second, RA subjects were matched by sex and BMI to adults 10-20 years older. SMF, IMAT and SAT were measured with Computed Tomography images of the mid-thigh region. We used parametric or non-parametric related-sample tests to compare fat accumulation between RA subjects and healthy adults.

Results

In the first study SMF was significantly higher in the RA cohort

SUBMITTER: Khoja SS 

PROVIDER: S-EPMC10119702 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature