Adverse Events of Cannabidiol Use in Patients With Epilepsy: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Epilepsy is one of the most common neurologic disorders globally. Cannabidiol (CBD) has been approved for the treatment of epilepsy, but its use has been associated with several different adverse events (AEs).

Objective

To investigate the frequency and risk of AEs developing in patients with epilepsy who are using CBD.

Data sources

PubMed, Scopus, Web of Science, and Google Scholar were searched for relevant studies published from database inception up to August 4, 2022. The search strategy included a combination of the following keywords: (cannabidiol OR epidiolex) AND (epilepsy OR seizures).

Study selection

The review included all randomized clinical trials that investigated at least 1 AE from the use of CBD in patients with epilepsy.

Data extra

SUBMITTER: Fazlollahi A 

PROVIDER: S-EPMC10119734 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature