Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration.

ABSTRACT:

Importance

Central serous chorioretinopathy (CSC) is a serous maculopathy of unknown etiology. Two of 3 previously reported CSC genetic risk loci are also associated with AMD. Improved understanding of CSC genetics may broaden our understanding of this genetic overlap and unveil mechanisms in both diseases.

Objective

To identify novel genetic risk factors for CSC and compare genetic risk factors for CSC and AMD.

Design, setting, and participants

Using International Classification of Diseases, Ninth (ICD-9) and Tenth (ICD-10) Revision code-based inclusion and exclusion criteria, patients with CSC and controls were identified in both the FinnGen study and the Estonian Biobank (EstBB). Also included in a meta-analysis were previously reported patients with chronic CSC an

SUBMITTER: Ramo JT 

PROVIDER: S-EPMC10119776 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature