Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia.

ABSTRACT:

Background

Preeclampsia is a syndrome of high blood pressure (BP) with end organ damage in late pregnancy that is associated with high circulating soluble VEGF receptor (sFlt1 [soluble Fms-like tyrosine kinase 1]). Women exposed to preeclampsia have a substantially increased risk of hypertension after pregnancy, but the mechanism remains unknown, leaving a missed interventional opportunity. After preeclampsia, women have enhanced sensitivity to hypertensive stress. Since smooth muscle cell mineralocorticoid receptors (SMC-MR) are activated by hypertensive stimuli, we hypothesized that high sFlt1 exposure in pregnancy induces a postpartum state of enhanced SMC-MR responsiveness.

Methods

Postpartum BP response to high salt intake was studied in women with prior preeclampsia. M

SUBMITTER: Biwer LA 

PROVIDER: S-EPMC10119809 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature