A systematic outbreak investigation of SARS-CoV-2 transmission clusters in a tertiary academic care center.

ABSTRACT:

Background

We sought to decipher transmission pathways in healthcare-associated infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within our hospital by epidemiological work-up and complementary whole genome sequencing (WGS). We report the findings of the four largest epidemiologic clusters of SARS-CoV-2 transmission occurring during the second wave of the pandemic from 11/2020 to 12/2020.

Methods

At the University Hospital Basel, Switzerland, systematic outbreak investigation is initiated at detection of any nosocomial case of SARS-CoV-2 infection, as confirmed by polymerase chain reaction, occurring more than five days after admission. Clusters of nosocomial infections, defined as the detection of at least two positive patients and/or healthcare

SUBMITTER: von Rotz M 

PROVIDER: S-EPMC10119817 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature