Emerging drugs targeting cellular redox homeostasis to eliminate acute myeloid leukemia stem cells.

ABSTRACT: Acute myeloid leukemia (AML) is a very heterogeneous group of disorders with large differences in the percentage of immature blasts that presently are classified according to the specific mutations that trigger malignant proliferation among thousands of mutations reported thus far. It is an aggressive disease for which few targeted therapies are available and still has a high recurrence rate and low overall survival. The main reason for AML relapse is believed to be due to leukemic stem cells (LSCs) that have unlimited self-renewal capacity and long residence in a quiescent state, which promote greater resistance to traditional therapies for this cancer. AML LSCs have low oxidative stress levels, which appear to be caused by a combination of low mitochondrial activity and high activity of

SUBMITTER: Costa RGA 

PROVIDER: S-EPMC10119960 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature