Molecular profiling of the stroke-induced alterations in the cerebral microvasculature reveals promising therapeutic candidates.

ABSTRACT: Stroke-induced cerebral microvascular dysfunction contributes to aggravation of neuronal injury and compromises the efficacy of current reperfusion therapies. Understanding the molecular alterations in cerebral microvessels in stroke will provide original opportunities for scientific investigation of novel therapeutic strategies. Toward this goal, using a recently optimized method which minimizes cell activation and preserves endothelial cell interactions and RNA integrity, we conducted a genome-wide transcriptomic analysis of cerebral microvessels in a mouse model of stroke and compared these transcriptomic alterations with the ones observed in human, nonfatal, brain stroke lesions. Results from these unbiased comparative analyses have revealed the common alterations in mouse stroke micro

SUBMITTER: Callegari K 

PROVIDER: S-EPMC10120001 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature