Compensatory relationship between low-complexity regions and gene paralogy in the evolution of prokaryotes.

ABSTRACT: The evolution of genomes in all life forms involves two distinct, dynamic types of genomic changes: gene duplication (and loss) that shape families of paralogous genes and extension (and contraction) of low-complexity regions (LCR), which occurs through dynamics of short repeats in protein-coding genes. Although the roles of each of these types of events in genome evolution have been studied, their co-evolutionary dynamics is not thoroughly understood. Here, by analyzing a wide range of genomes from diverse bacteria and archaea, we show that LCR and paralogy represent two distinct routes of evolution that are inversely correlated. The emergence of LCR is a prominent evolutionary mechanism in fast evolving, young protein families, whereas paralogy dominates the comparatively slow evolution

SUBMITTER: Persi E 

PROVIDER: S-EPMC10120016 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature