Contextual modifiers of healthspan, lifespan, and epigenome in mice under chronic social stress.

ABSTRACT: Sustained life stress and low socioeconomic status are among the major causes of aging-related diseases and decreased life expectancy. Experimental rodent models can help to identify the underlying mechanisms, yet very few studies address the long-term consequences of social stress on aging. We conducted a randomized study involving more than 300 male mice of commonly used laboratory strains (C57BL/6J, CD1, and Sv129Ev) chosen for the spontaneous aggression gradient and stress-vulnerability. Mice were exposed to a lifelong chronic psychosocial stress protocol to model social gradients in aging and disease vulnerability. Low social rank, inferred based on a discretized aggression index, was found to negatively impact lifespan in our study population. However, social rank interacted with gen

SUBMITTER: Razzoli M 

PROVIDER: S-EPMC10120026 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature