A spatially resolved elemental nanodomain organization within acidocalcisomes in Trypanosoma cruzi.

ABSTRACT: How are ions distributed in the three-dimensional (3D) volume confined in a nanoscale compartment? Regulation of ionic flow in the intracellular milieu has been explained by different theoretical models and experimentally demonstrated for several compartments with microscale dimensions. Most of these models predict a homogeneous distribution of ions seconds or milliseconds after an initial diffusion step formed at the ion translocation site, leaving open questions when it comes to ion/element distribution in spaces/compartments with nanoscale dimensions. Due to the influence of compartment size on the regulation of ionic flow, theoretical variations of classical models have been proposed, suggesting heterogeneous distributions of ions/elements within nanoscale compartments. Nonetheless, su

SUBMITTER: Girard-Dias W 

PROVIDER: S-EPMC10120040 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature